DENVER (KDVR) — Police are investigating a multi-car crash that shut down Colfax Avenue.

Around 6:30 a.m. Monday, SkyFOX flew over a large scene on eastbound Colfax just east of Interstate 225. Several ambulances and fire trucks responded to the crash.

According to the Aurora Police Department, seven vehicles were involved in the crash. An RTD bus received minor damage from debris, but no one on the bus was injured.

Five injuries were reported, including two people who were taken to the hospital with serious injuries and three others who had minor injuries.

Aurora’s Traffic Investigation Unit is investigating a medical issue as a possible contributing cause to the crash.

Just before 9:30 a.m., Aurora Police said eastbound Colfax remained closed and was expected to be closed for several more hours. Traffic from Colfax was diverted onto southbound I-225.

Police were asking drivers to consider using 6th Avenue as an alternate east-west route.