Lanes three through five of I-25 remain closed at Belleview Avenue with no estimated time of reopening.
The incident happened around 2:53 a.m. near northbound I-25 and Belleview Avenue when a box truck crashed.
The driver of the truck was not injured.
Police said the fuel tanks of the truck ruptured, spilling less than 100 gallons of diesel fuel onto the road.
The cause of the crash is under investigation.
This is a developing story. Please check back for updates.