Darla Rodriguez, 29, and 37-year-old Adam Vilders are being held at the Arapahoe County Jail on second-degree murder charges.
Littleton police officers responded to a call of shots fired in the 2700 block of West Riverwalk Circle around 3:20 a.m. and found Luke Scott Clayton, 28, who had been shot multiple times in the chest.
Clayton died on the scene.
Littleton police said at the time they were searching for a white sedan and a white Honda CRV in relation to the shooting.
The two suspects were arrested on July 22.