BERTHOUD, Colo. — A head-on crash closed both directions of U.S. 287 south of Berthoud on Wednesday morning, the Colorado State Patrol said.
The crash happened about 7:30 a.m. and involved three vehicles. The third vehicle became involved after hitting road debris, the Colorado State Patrol said.
One of the vehicles ended up going in the wrong direction on the highway, leading to the crash.
The driver of the wrong-way vehicle was taken to Longmont United Hospital with serious injuries. The other driver was airlifted to Medical Center of the Rockies with unknown injuries.
The driver of the third vehicle was not injured.
U.S. 287 was closed between Vermillion and Yellowstone roads. There was no estimate for when the highway would reopen.